SESSION 1
EARLY BENEFITS OF IMMUNE RECONSTITUTION IN MS
Chairperson: Dr. A. Momani
OPENING AND INTRODUCTION
INTEGRATING IMMUNE RECONSTITUTION THERAPIES
This session will explore the history of DMT leading up to IRTs, with a focus on Mavenclad. Safety considerations include managed lymphopenia, infection monitoring, and tailored patient selection criteria. The discussion emphasizes early IRT initiation to optimize long-term disease control in eligible patients.

Prof. M. Sahraian
LINKING MODE OF ACTION TO POTENTIAL LONG-TERM EFFICACY
This session explores Mavenclad unique mode of action as an IRT, selectively targeting lymphocytes to disrupt MS disease activity. Its intermittent dosing provides sustained efficacy by
allowing immune repopulation while maintaining long-term disease control. The approach minimizes continuous immunosuppression, offering durable benefits with a limited treatment course.

Dr. E. Darmun
TRANSLATING RESEARCH INTO DAILY CLINICAL APPLICATIONS
We will demonstrate Mavenclad’s real-world effectiveness, showing better results than other oral platform DMTs in relapse reduction and treatment persistence. Early use is linked to sustained disease control and improved patient outcomes. The session explores its practical clinical application and safety advantages

Prof. S. Braune
BENEFITS OF IMMUNE RECONSTITUTION THERAPIES EARLY IN RMS
This panel discussion explores the benefits of Mavenclad as an IRT in early relapsing MS. Experts will highlight its unique mechanism, durable efficacy from real-world data, and practical advantages like short-course oral dosing. Key topics include safety comparisons with anti-CD20 therapies and lifestyle benefits for patients

Prof. M. Sahraian

Dr. M. Poursadeghfard

Prof. S. Braune
SESSION 2
EARLY USE OF MAVENCLAD: PATIENT-CENTRIC STRATEGIES
Chairperson: Prof. J. Sastre-Garriga
MAVENCLAD IN PRACTICE: EXPERIENCE DRIVEN CASE PRESENTATION
In this session, the speaker will present two Interactive clinical cases with the HCPs demonstrating the application of Mavenclad in MS management. One case features a treatment-naive patient starting Mavenclad, while the other focuses on a patient who was switched to Mavenclad after inadequate response to previous therapies. The discussion will emphasize the clinical decision-making process, treatment outcomes, and outcomes seen from both cases.

Prof. S. Braune
SEQUENCING AND EARLY USE OF MAVENCLAD: MANAGING DMT TRANSITIONS
This session will focus on the strategic approach to sequencing DMTs with a focus on switching to Mavenclad. It will outline the criteria for identifying suitable candidates for the switch, addressing timing and patient considerations, as well as the clinical benefits of early intervention with Mavenclad. It will provide practical guidance on optimizing treatment pathways to enhance patient outcomes.

Prof. M. Sahraian
Personalized Care Plans for MS Patients
This panel discussion focuses on individualized MS care, exploring how Mavenclad fits into tailored treatment strategies. Experts will address patient selection, switching protocols from anti-CD20 therapies, and optimal monitoring during washout periods from various DMTs. The session will provide practical insights for optimizing outcomes with Mavenclad in diverse clinical scenarios.

Prof. M. Sahraian

Prof. S. Braune

Prof. J. Sastre-Garriga
SESSION 3
Chairperson: Prof. S. M. Nabavi
Advanced MRI Techniques for Monitoring Mavenclad Efficacy
This session explores the significance of early and accurate diagnosis of MS and the role of Mavenclad in initiating effective therapy. The discussion will highlight how timely diagnosis can
lead to better treatment outcomes and how Mavenclad can be integrated into early intervention strategies.

Prof. J. Sastre-Garriga
Mavenclad and Rebif: Efficacy in Special MS Population
This session will focus on the use of Mavenclad and Rebif in special populations, particularly the elderly and women planning for pregnancy. A fertility specialist will provide insights on emotional and mental health in fertility for both partners and addressing anxieties, fears, and the need for coping mechanisms and support networks. The session will address the challenges for optimizing therapy while supporting reproductive health and overall well-being in patients with MS.

Prof. M. Sahraian

Prof. S. Braune

Dr. A. Akbari Sene
Closing
